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The Scientific World Journal
Volume 2012, Article ID 571596, 6 pages
Research Article

INVO Procedure: Minimally Invasive IVF as an Alternative Treatment Option for Infertile Couples

Centro Colombiano de Fertilidad y Esterilidad (CECOLFES) S.A.S., Calle 102 No. 14A-15, 56769 Bogotá, Colombia

Received 15 October 2011; Accepted 8 December 2011

Academic Editor: João B. A. Oliveira

Copyright © 2012 Elkin Lucena et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Intravaginal culture (IVC), also called INVO (intravaginal culture of oocytes), is an assisted reproduction procedure where oocyte fertilization and early embryo development are carried out within a gas permeable air-free plastic device, placed into the maternal vaginal cavity for incubation. In the present study we assessed the outcome of the INVO procedure, using the recently designed INVOcell device, in combination with a mild ovarian stimulation protocol. A total of 125 cycles were performed. On average 6.5 oocytes per cycle were retrieved, and a mean of 4.2 were placed per INVOcell device. The cleavage rate obtained after the INVO culture was 63%. The procedure yielded 40%, 31.2%, and 24% of clinical pregnancy, live birth, and single live birth rates per cycle, respectively. Our results suggest that the INVO procedure is an effective alternative treatment option in assisted reproduction that shows comparable results to those reported for existing IVF techniques.