Robust Optimization of Alginate-Carbopol 940 Bead Formulations

Table 5

ANOVA results: effect of the variables on 𝑡_50%, AUC, % entrapment (EE), swelling percentage (SR), shape factor (SF), and particle size (DM).

Factors	𝑡50%			AUC			EE
	𝐹-ratio	𝑃	𝐼-ℎ𝑎𝑡	𝐹-ratio	𝑃	𝐼-ℎ𝑎𝑡	𝐹-ratio	𝑃	𝐼-ℎ𝑎𝑡
A	89.52	<0.001	16.48	144.1	<0.001	−1892	11.2	0.004	5.57
B	2072	<0.001	97.11	1070	<0.001	−6316	0.27	0.607	1.07
C	132.5	<0.001	24.56	136	<0.001	−2252	1.41	0.25	2.42
D	564	<0.001	50.67	251.7	<0.001	−3063	0.003	0.955	−0.12
E	172.9	<0.001	−28.06	52.87	<0.001	1404	1.27	0.274	2.30
F	83.07	<0.001	−19.44	21.36	<0.001	892.2	2.18	0.157	3.01
G	0.01	0.918	−0.22	0.01	0.921	−19.4	0.67	0.425	1.66
H	213.4	<0.001	−31.17	3.20	0.082	345.2	0.53	0.474	−1.49
Factors	SR			SF			DM
	𝐹-ratio	𝑃	𝐼-ℎ𝑎𝑡	F-ratio	𝑃	𝐼-ℎ𝑎𝑡	𝐹-ratio	𝑃	𝐼-ℎ𝑎𝑡
A	1842	<0.001	592	34.79	<0.001	−0.072	12.78	<0.001	0.255
B	1208	<0.001	−587.2	0.78	0.383	0.013	2.19	0.148	0.128
C	808.8	<0.001	−480.5	11.9	<0.001	0.051	2.19	0.148	0.130
D	274.4	<0.001	279.9	69.35	<0.001	−0.124	1.69	0.201	0.115
E	0.00	0.99	−0.22	4.49	0.041	−0.032	2.73	0.108	−0.142
F	62.8	<0.001	−133.9	100.4	<0.001	−0.149	0.80	0.377	0.077
G	5856	<0.001	−1293	23.4	<0.001	−0.072	8.78	0.005	0.261
H	25.09	<0.001	84.64	15.63	<0.001	0.059	8.15	0.007	−0.251