Clinical Study

CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation

Figure 4

Lymphocyte subpopulations and Treg in patients with cGVHD and in patients without cGVHD. Box plot graphs of lymphocyte subpopulation frequencies in patients and healthy controls. The graphs show the dispersion around the median for patients without cGVHD ( 𝑛 = 3 8 ), for patients with cGVHD ( 𝑛 = 4 6 ), and for normal controls ( 𝑛 = 2 0 ). The line across each box represents the median, the bottom edge the first quartile, and the top edge the third quartile, the error bars represent the dispersion within the 95% confidence interval and the dots represent extreme values. Differences between the groups were explored using the Mann-Whitney U-test. Significant differences between the groups are shown above ( 𝑃 < 0 . 0 5 ). All other differences between the median values were not significant ( 𝑃 > 0 . 0 5 ). CD: cluster of differentiation, Treg: regulatory T cells, and cGVHD, chronic graft versus host disease.
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