Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and Migration
Table 1
Frequency of the β-thalassemia mutations among different provinces of the Iran*.
Provinces
Mutation
Sample size
IVS-II-1 (G > A)
IVS-I-5 (G > C)
Codons 8/9 (+G)
IVS-I-110 (G > A)
IVS-I-6 (T > C)
Codons 36/37 (−T)
25 bp del.
IVS-I-1 (G > A)
IVS-II-745 (G > C)
Codon 39 (C > T)
Codon 44 (−C)
Codon 30 (G > C)
Codon 5 (−CT)
Codon 8 (−AA)
Studied location
West Azerbaijan
75
50.7%
a
8.0%
16.0%
5.3%
8.0%
9.3%
2.7%
A
East Azerbaijan
80
32.0%
2.6%
18.7%
16.0%
22.6%
5.3%
A
Ardebil
142
17.8%
7.0%
30.0%
25.4%
2.5%
0.6%
6.3%
6.3%
3.8%
A
Kurdistan
33
31.8%
1.5%
13.6%
1.5%
1.5%
1.5%
4.5%
6.0%
B
Khuzestan
208
12.0%
8.6%
17.3%
16.8%
10.5%
23.3%
C
Lorestan
65
27.7%
4.6%
10.7%
11.5%
33.8%
0.7%
1.6%
0.7%
D
Chaharmahal and Bakhtiari
57
29.8%
10.5%
31.5%
24.5%
3.5%
1.7%
D
Bushehr
104
13.0%
7.7%
8.2%
5.8%
1.5%
24.4%
9.1%
3.3%
3.3%
3.3%
2.4%
E
Fars
70
47.1%
1.4%
1.4%
21.4%
1.4%
1.4%
8.6%
F
Kerman
50
16%
44%
12.0%
4.0%
G
Sistan and Baluchistan
224
1.4%
76.5%
3.7%
11.1%
0.7%
0.7%
1.4%
0.7%
0.5%
G
Yazd
49
32.5%
44.8%
4.0%
6.1%
2.0%
2.0%
G
Hormozgan
70
4.2%
90.0%
5.8%
G
Esfahan
205
29.0%
26.0%
8.0%
2.9%
17.5%
2.0%
3.9%
4.4%
8.3%
H
Semnan
52
40.3%
5.7%
23.3%
3.8%
3.8%
H
Tehran
638
42.4%
8.4%
16.6%
7.8%
2.0%
7.5%
0.8%
0.1%
1.5%
1.3%
H
Mazandaran
77
68.8%
3.8%
1.3%
6.4%
H
Gilan
65
49.2%
10.7%
9.2%
9.2%
3.0%
H
Qazvin
60
50.0%
1.6%
5.0%
15.0%
3.3%
3.3%
3.3%
1.6%
H
Hamedan
47
34.0%
8.5%
19.1%
8.5%
2.1%
10.6%
H
Khorasan
70
10.0%
65.7%
8.5%
I
aIt has been written in bold the most frequent mutations in each province.
*This table includes data from published data in local and international references and unpublished data during routinely diagnostic tests. Also the data is not available for blank areas.
