Review Article
A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers
Table 15
Comparative pharmacokinetic parameters after oral administration of metronidazole and in combination with piperine in rabbits [
98].
| | Pharmacokinetic | Metronidazole | Metronidazole + piperine | | parameters |
| | (ng/mL) | 3,805.89 ± 233.8 | 6,007.07 ± 348.8 | |
AUC0–24 (ng·h/mL) | 45,073.75 ± 713.7 | 84,980.98 ± 345.6 | | (h) | 1.66 ± 0.57 | 1.66 ± 0.57 | | (mL/h) | 0.06 ± 0.02 | 0.04 ± 0.02 | | (h) | 1.48 ± 1.23 | 12.24 ± 1.04 | | (L) | 2.69 ± 0.23 | 1.48 ± 0.65 |
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