The Scientific World Journal / 2012 / Article / Tab 23 / Review Article
A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers Table 23 Percent enhancement in bioavailability of different compounds by supplementation of bioactive fractions from
C. cyminum and its combination with piperine [
166 ,
167 ].
Category Compound Percent enhancement BE from C. cyminum BE from C. cyminum + piperine Macrolides Azithromycin 83 97 Erythromycin 75 95 Roxithromycin 67 103 Cephalosporins Cefalexin 60 75 Cefadroxil 90 79 Penicillins Amoxycillin 75 98 Cloxacillin 94 95 Aminoglycosides Kanamycin 95 110 Fluoroquinolones Ciprofloxacin 52 47 Pefloxacin 47 57 Ofloxacin 61 73 Antifungal Fluconazole 170 126 Ketoconazole 136 156 Antiviral Acyclovir 110 98 Zidovudine 330 415 CNS drugs Alprazolam 60 104 Anticancer Methotrexate 125 30 5-Fluorouracil 335 435 Doxorubicin 85 103 Cisplatin 70 79 Cardiovascular Amlodipine 55 103 Propranolol 135 210 Lisinopril 83 98 Anti-inflammatory/Antiarthritic Diclofenac 65 108 Nimesulide 168 150 Piroxicam 70 107 Antituberculosis/Antileprosy Rifampicin 250 365 Dapsone 60 75 Ethionamide 78 65 Cycloserine 89 90 Antihistamines Salbutamol 110 85 Theophylline 87 75 Bromhexine 50 90 Corticosteroids Dexamethasone 85 105 Betamethasone 95 82 Immuno-suppressants Cyclosporin A 156 275 Tacrolimus 75 117 Antiulcer Ranitidine 117 89 Cimetidine 123 105 Vitamins Vitamin A (1 mg/kg) 26 18 Vitamin B1 (10 mg/kg) 37 33 Antioxidants β -Carotene (15 mg/kg) 45 53 Silymarin (5 mg/kg) 32 41 Herbal products Curcumin (50 mg/kg) 39 29 Herbal plants Echinacea 72 90 Tinospora cordifolia 98 152 Picrorhiza kurroa 78 115 Andrographis paniculata 72 68 Emblica ribes 72 60 Asparagus racemosus 35 72 Withania somnifera 55 65 Amino acids Methionine (20 mg/kg) 27 30 Lysine (40 mg/kg) 35 29 Leucine (50 mg/kg) 31 32 Valine (25 mg/kg) 25 24 Isoleucine (25 mg/kg) 40 22 Essential elements Iron (0.5 mg/kg) 23 29
