A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers
Table 32
Pharmacokinetic parameters of doxorubicin (50 mg/kg) and in the presence or absence (control) of quercetin (0.6, 3, and 15 mg/kg) after oral administration [215].
Parameters
Doxorubicin (control)
Doxorubicin + quercetin
0.6 mg/kg
3 mg/kg
15 mg/kg
AUC0–∞ (ng·h/mL)
186 ± 44.6
244 ± 63.2*
344 ± 98.6**
439 ± 107.3**
(ng/mL)
20.2 ± 5.13
27.3 ± 6.42*
38.0 ± 9.28*
45.6 ± 11.16**
(h)
0.25
0.25
0.25
0.25
(L/min)
6.54 ± 1.45
5.06 ± 1.13
2.88 ± 0.64*
2.23 ± 0.52*
(h)
13.5 ± 3.32
13.7 ± 3.41
13.8 ± 3.51
13.9 ± 3.82
AB (%)
3.04 ± 0.74
4.01 ± 0.94*
5.58 ± 1.32**
7.12 ± 1.71**
RB (%)
100
132
185
236
n = 7, mean ± SD; *P < 0.05, **P < 0.01 significant difference compared to control.
