Research Article

Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement

Table 1

Summary of saliva proteins with expression change during orthodontic treatment.

Spot no.Protein nameAccession number (UniProt)MW (kDa)/pIPeptides matched/% coverage (Protein score)Expression change
TheoreticalExperimental

1Protein S100-A9 (S100 calcium-binding protein A9) (Calgranulin-B)P0670213.2/5.7114.5/5.474/24% (121)Downregulated at day 14
2Serum albumin precursorP0276869.3/5.9214.8/7.008/11% (105)Downregulated at day 14
3Immunoglobulin J chainP0159115.5/4.6234.0/3.8610/30% (220)Downregulated at day 14
4Immunoglobulin J chainP0159115.5/4.6236.4/3.406/27% (198)Downregulated at day 14
5Ig alpha-1 chain C regionP0187637.6/6.0844.76/6.919/20% (260)Downregulated at day 14
6Cysteine-rich secretory protein 3 precursor (CRISP-3)P5410827.6/8.0943.25/8.902/6% (94)Present only at day 14
7Hemoglobin subunit beta (Hemoglobin beta chain) (Beta-globin)P6887115.9/6.7514.83/9.506/27% (158)Present only at day 0
814-3-3 protein σ (Stratifin) (Epithelial cell marker protein 1)P3194727.7/4.6844.76/4.205/22% (147)Present only at day 0

These are proteins that show statistically significant change ( 𝑃 < 0 . 5 ) between day 0 and day 14 of orthodontic treatment.