Research Article

Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement

Table 2

Summary of identified proteins and their known functions.

ProteinKnown function

Protein S100-A9 (S100 calcium-binding protein A9) (Calgranulin-B)(i) Calcium-binding protein.
(ii) Promotes phagocyte migration and infiltration of granulocytes at sites of wounding.
(iii) Plays a role as a proinflammatory mediator in acute and chronic inflammation.

Serum albumin precursor(i) Good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin, and drugs.
(ii) Main function is the regulation of the colloidal osmotic pressure of blood.
(iii) Major zinc transporter in plasma.

Immunoglobulin J chain(i) Serves to link two monomer units of either IgM or IgA.
(ii) Help to bind IgM or IgA to secretory component.

Ig alpha-1 chain C region(i) Major immunoglobulin class in body secretions.
(ii) Serve both to defend against local infection and to prevent access of foreign antigens.

Cysteine-rich secretory protein 3 precursor (CRISP-3)(i) Innate immune response
(ii) Potential biological marker for prostate cancer

Hemoglobin subunit beta (Hemoglobin beta chain) (Beta-globin)Involved in oxygen transport from the lung to the various peripheral tissues.

14-3-3 protein σ (Stratifin) (Epithelial cell marker protein 1)(i) Adapter protein.
(ii) Binds to a large number of partners, generally results in the modulation of the activity of the binding partner.