Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model
Figure 1
(a) Chronic bronchitis. The lamina propria and submucosa in this large bronchus are completely occupied by lymphocytes and plasma cells. The surface epithelium shows squamous metaplasia (arrows). Desquamated cells are admixed with mucus. PAS stain, 160x. (b) Plugs of fibrin. Fibrin occluding alveolar spaces (arrows) undergoes organization accompanied by active macrophages within alveolar spaces. H&E stain, 160x. (c) Alveolar organisation of exudates with proliferation of collagen within fibrin scaffolds (arrows) as well as in interstitium. Same field as Figure 1(b). Masson’s Trichrome stain, 160x. (d) Alveolar epithelialisation. An area almost completely restored with type II pneumocytes proliferation (arrows). H&E stain, 160x. (e) Bronchiolitis obliterans. Bronchiolitis obliterans with various degrees of severity were recorded. In this image, the lesion includes fibroplasia and neovascularisation (arrow). PAS stain, 240x. (f) Goblet cells metaplasia. Epithelial hyperplasia and goblet cell metaplasia (arrows) were recognized in some small bronchioles such as this image with some neutrophils and mucus exudation into the lumen. Alcian blue stain, 240x.
