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The Scientific World Journal
Volume 2012, Article ID 681534, 6 pages
http://dx.doi.org/10.1100/2012/681534
Research Article

Improvement of the Bioavailability and Glycaemic Metabolism of Cinnamon Oil in Rats by Liquid Loadable Tablets

1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2College of Food and Biological Engineering, Shandong Polytechnic University, Jinan 250353, China

Received 24 October 2011; Accepted 12 December 2011

Academic Editor: Javed Ali

Copyright © 2012 Chunchao Han and Bo Cui. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study is to investigate the bioavailability and glycaemic metabolism of cinnamon oil (CIO) carried by liquid-loadable tablets (CIO-LLTs), the carrier of a CIO self-emulsifying formulation (CIO-LS). The results of tests performed to evaluate the physical properties of the CIO-LLT complied with Chinese Pharmacopeia (2010). The release profile suggested that the CIO-LLT preserved the enhancement of in vitro dissolution of cio. After orally administration, the plasma concentration-time profile and pharmacokinetic parameters suggested that a significant increase (𝑃<0.0001) in the 𝐶max, AUC and F were observed in the CIO-LLT. The blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic rats (𝑃<0.05, 𝑃<0.01, resp.), while the level of insulin secretion was markedly elevated in alloxan-induced hyperglycemic rats (𝑃<0.05). The alloxan-damaged pancreatic 𝛽-cells of the rats were partly recovered gradually after the rats were administered with CIO-LLT 45 days later. CIO-LLT could improve the bioavailability and glycaemic metabolism of CIO.