Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering

<table>Biocompatibility of fibroblast cells on CS/SF blend films: (a) fibroblast cells adhesion on the blend film after 3 days of incubation, the white arrow showing cell-cell interaction, (b) fibroblast cells viability on the different blend films, and (c) type I collagen mRNA expression of fibroblast cells cultured on the blend films and tissue culture plate (TCPs) at day 14. Data represent mean ± standard error (<svg height="10.8125" id="M16" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 35.099998 10.8125" width="35.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.8125)">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">4</tspan>
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</svg>). Student’s <i>t</i>-test showed a significant difference in day 7 (*<svg height="11.25" id="M17" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
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<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">5</tspan>
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</svg>) and day 14 (**<svg height="11.0625" id="M18" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 63.962502 11.0625" width="63.962502" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="44.810753" y="0">1</tspan>
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</svg>) as compared to day 1 (CF: chitosan : fibroin ratio).</table>

The Scientific World Journal

fig8

Figure 8

Figure 8: Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering 