Potential Canonical Wnt Pathway Activation in High-Grade Astrocytomas

Table 3

Results from multivariate survival analysis. Hazard ratios were adjusted for WHO grade, age at diagnosis, and extent of tumour resection.

Antigen expression	HR (95% CI)	𝑃 value
β-Catenin
In WHO grade II–IV (≤50% versus >50% positive cells)	1.49 (0.83–2.69)	0.18
In WHO grade II (≤50% versus >50% positive cells)	Not determined	Not determined
In WHO grade III (≤50% versus >50% positive cells)	Not determined	Not determined
In WHO grade IV (≤50% versus >50% positive cells)	1.63 (0.90–2.95)	0.10
β-Catenin-P654
In WHO grade II–IV (≤5% versus >5% positive cells)	0.85 (0.63–1.14)	0.27
In WHO grade II (≤5% versus >5% positive cells)	0.37 (0.14–0.96)	0.04
In WHO grade III (≤5% versus >5% positive cells)	0.65 (0.10–4.04)	0.64
In WHO grade IV (≤5% versus >5% positive cells)	0.96 (0.70–1.32)	0.81