Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease

Figure 1

SPM8 maps of voxel-based correlations between [¹¹C]PIB tracer uptake and CSF BACE1 activity. Anatomical localization as projected on axial sections of a normal T1-weighted MRI, spatially normalized into the MNI template at the given 𝑧 coordinates in Talairach’s space (𝑃<0.01 uncorrected for display purposes; voxels outside of the brain and in the cerebellum are artifacts due to this threshold); color bars represent 𝑍-scores; images are displayed in neurological orientation (right side is right).