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The Scientific World Journal
Volume 2012 (2012), Article ID 718023, 8 pages
http://dx.doi.org/10.1100/2012/718023
Research Article

Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives

1Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Off Campus, JSS University, Mysore 570015, India
2Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Rocklands, Ooty 643001, India

Received 31 October 2011; Accepted 13 December 2011

Academic Editor: Concettina La Motta

Copyright © 2012 Selvaraj Jubie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid was reacted with three different ketones and formaldehyde to give the corresponding Mannich bases in satisfactory yield. Their structures were confirmed by using 1H NMR, IR, and mass analysis. In pharmacological evaluation, the synthesized compounds showed its curative effect against ethidium-bromide-induced demyelination in rats. For the purpose, different screening methods such as open field exploratory behavior test, rota rod test, grip strength test, beam walk test, and photo actometer test were performed. Ethidium bromide induction showed muscle weakness; muscle discoordination; loss of locomotor activity, and so forth, the synthesized drugs reversed all the above-mentioned neuromuscular disorders caused by ethidium bromide administration.