Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State

Figure 14

Concentration macrocycle D versus time for kinetic model 8. [A]₀ = [B]₀ = 0.005 M, [Br⁻]₀ = 0.0025 M, 𝑘₁ = 10 M⁻¹ min⁻¹, 𝑘_1𝑐 = 4000 M⁻² min⁻¹, 𝑘₂ = 0.5 min⁻¹, (a) 𝑘_2𝑐 = 200 M⁻¹ min⁻¹, and (b) 𝑘_2𝑐 = 400 M⁻¹ min⁻¹.

(a)

(b)