Review Article

The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells: Stromal Derived Factor 1 Is Not the Only Player in the Game

Figure 1

Homing of HSPCs to BM—the involvement of new chemotactic and priming factors. Evidence has accumulated that HSPCs home to BM in response not only to SDF-1 but also in response to some bioactive lipids (S1P and C1P), as well as extracellular nucleotides (ATP and UTP). The responsiveness of HSPCs to an SDF-1 gradient is also positively modulated by several priming molecules, including peptides of the cationic antimicrobial peptide (CAMPs) family, and PGE2.
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