The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells: Stromal Derived Factor 1 Is Not the Only Player in the Game
Figure 3
Cationic antimicrobial peptides (CAMPs) C3a and LL-37 enhance the responsiveness of murine BM- and human UCB-derived HSPCs to an SDF-1 gradient: Chemotaxis of murine BM CFU-GM in response to different concentrations of SDF-1 with and without C3a or LL-37 [20, 55]. Values are the fold increase in the number of migrated cells compared to the number of migrated cells in medium alone. Gray bars indicate the presence of LL-37 (2.5 μg/mL), cross-hatched bars the presence of C3a (1 μg/mL) in the lower transwell chambers, and black bars indicate PBS only. The data represent the combined results from three independent experiments performed in duplicate per group ().
