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The Scientific World Journal
Volume 2012, Article ID 792756, 8 pages
http://dx.doi.org/10.1100/2012/792756
Clinical Study

The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease

1School of Nutrition, Chung Shan Medical University, No. 110, Section 1, Jianguo N. Road, Taichung 40201, Taiwan
2The Intensive Care Unit, Taichung Veterans General Hospital, No. 160, Section 3, Chung-Kang Road, Taichung 40705, Taiwan
3Department of Nutrition, Chung Shan Medical University Hospital, No. 110, Secion 1, Jianguo N. Road, Taichung 40201, Taiwan
4Department of Nutrition and Institute of Biomedical Nutrition, HungKuang University, No. 34 Chung-Chie Road, Sha Lu, Taichung 43346, Taiwan

Received 3 February 2012; Accepted 21 February 2012

Academic Editors: D. Détaint and H. Ooboshi

Copyright © 2012 Bor-Jen Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A higher oxidative stress may contribute to the pathogenesis of coronary artery disease (CAD). The purpose of this study was to investigate the relationship between coenzyme Q10 concentration and lipid peroxidation, antioxidant enzymes activities and the risk of CAD. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery were assigned to the case group (). The control group () comprised healthy individuals with normal blood biochemical values. The plasma coenzyme Q10, malondialdehyde (MDA) and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)) were measured. Subjects with CAD had significant lower plasma coenzyme Q10, CAT and GPx activities and higher MDA and SOD levels compared to those of the control group. The plasma coenzyme Q10 was positively correlated with CAT and GPx activities and negatively correlated with MDA and SOD. However, the correlations were not significant after adjusting for the potential confounders of CAD with the exception of SOD. A higher level of plasma coenzyme Q10 (≥0.52 μmol/L) was significantly associated with reducing the risk of CAD. Our results support the potential cardioprotective impact of coenzyme Q10.