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The Scientific World Journal
Volume 2012, Article ID 803678, 3 pages
Research Article

Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results

1Department of Interventional Radiology, Aretaieion Hospital, University of Athens, 76 Vas. Sofias Avenue, 115 28 Athens, Greece
2Department of Radiology, Aretaieion Hospital, 76 Vas. Sofias, 115 28 Athens, Greece
3Department of Vascular Surgery, Aretaieion Hospital, Aretaieion Hospital, 76 Vas. Sofias Avenue, 115 28 Athens, Greece

Received 25 October 2011; Accepted 17 November 2011

Academic Editor: Takuji Yamagami

Copyright © 2012 A. Chatziioannou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To present our results after short-term (1 month) intra-arterial infusion therapy of PGE1-alprostadil via a port system implanted in the ipsilateral external iliac artery (EIA) in patients with severe rest pain. Methods. Ten patients with severe rest pain were included. All patients showed extensive peripheral vascular disease below the knee. The tip of the catheter was introduced via a retrograde puncture in the ipsilateral external iliac artery (EIA). The patients received intraarterial infusion of PGE1, 20 mgr alprostadil daily, via the port catheter for 1 month. Results. Clinical success was evaluated according to subjective grading of pain (group A significant decrease, group B moderate decrease and group C no response). A significant decrease of rest pain was observed in 8 (group A, 80%) patients, a moderate decrease in 2 (Group B, 20%), whereas no patients demonstrated any significant response. Both patients of group B had Buergers' disease and continue to smoke during therapy. No peripheral thrombosis or clinical deterioration was noticed. Conclusion. Intraarterial infusion of PGE1 alprostadil on a daily basis, using a port catheter into the ipsilateral EIA, in selected patients with severe rest pain, seems to be very effective, without any serious complications.