Molecular Basis of Inhibitory Activities of Berberine against Pathogenic Enzymes in Alzheimer's Disease

Table 1

Theoretically estimated binding constants (𝐾_𝑑) of berberine with AChE, BChE, MAO-A, and MAO-B, and experimental IC₅₀.

Targets	Theoretical 𝐾𝑑 (μM)	Experimental IC50 (μM)
AChE	0.66	0.44 [14], 0.58 [15], 0.37 [16]
BChE	3.31	3.44 [14]
MAO-A	105.2	126 [19]
MAO-B	66.0	98.2 [20], 98.4 [21]