Human Papillomavirus Is Associated with Breast Cancer in the North Part of Iran

Table 1

The characteristics of study subjects and prevalence of HPV DNA status in breast cancer patients and noncancer controls.

Parameter	Cases^a (𝑁=79)	Controls^a (𝑁=51)	𝑃-value
Age (year ± SD)	47.77±12.552	34.20±9.704	≤0.0001 (𝑡-test)
HPV			𝟎.𝟎𝟎𝟐
Positive	15 (25.9)^b	1 (2.4)	𝐎𝐑𝟏𝟑.𝟗𝟓𝟑
Negative	43 (74.1)	40 (97.6)	(95% CI 1.762–110.526)
HPV genotype (% within type)
HPV-124	1 (6.25)	1 (100)
HPV-23	2 (12.5)
HPV-18	4 (25)
HPV-16	4 (25)
HPV-15	1 (6.25)
HPV-11	1 (6.25)
HPV-6	2 (12.5)
Unknown	1 (6.25)
HPV genotype (% within subjects)
High-risk type	8 (14)	0	0.005
Low-risk type	6 (10.5)	1 (2.4)
Negative	43 (75.5)	40 (97.6)
HPV genotype (% within subjects)
Mucosal type	11 (19)	0	0.002
EV-cutaneous type	4 (6.9)	1 (2.4)
Negative	43 (74.1)	40 (97.6)
Tumor type (% within tumor type)
IDC	67 (84.8)
ILC	8 (10.1)
IDC-ILC mix	1 (1.3)
MC	2 (2.5)
DC	1 (1.3)

^aSome of the subjects have been considered as missing value after quality examination of nucleic acid extraction.
^bNumbers in parentheses are percentages.