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The Scientific World Journal
Volume 2012 (2012), Article ID 859210, 6 pages
http://dx.doi.org/10.1100/2012/859210
Research Article

Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae)

1Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil
2Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, 58.051-970 João Pessoa, PB, Brazil

Received 28 October 2011; Accepted 4 January 2012

Academic Editors: C. Marchand and Y. Nomura

Copyright © 2012 Jackson Roberto Guedes da Silva Almeida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The ethanol extract from the fruits of Duguetia chrysocarpa was evaluated for its antinociceptive activity in chemical and thermal models of nociception in mice. The intraperitoneal administration of the ethanol extract (100, 200, and 400 mg/kg body weight) showed a dose-dependent inhibition of acetic-acid-induced abdominal writhes. The extract also produced a significant inhibition of both phases of the formalin test in all doses tested and increased the reaction time in hot-plate test at dose of 200 mg/kg. The data obtained suggest that the antinociceptive effect of the extract may be mediated via both peripheral and central mechanisms. The phytochemical investigation yielded the isolation of the benzenoid derivative 3-methoxy-4-ethoxy benzoic acid which is being reported for the first time in this genus.