Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2012, Article ID 901516, 9 pages
http://dx.doi.org/10.1100/2012/901516
Research Article

Immunostimulant Effect of Egyptian Propolis in Rabbits

1Department of Parasitology and Animal Diseases, National Research Center, Dokki, P.O. Box 12622, Giza, Egypt
2Department of Clinical Pathology, Faculty of Veterinary Medicine, Cairo University, P.O. Box 12211, Giza, Egypt

Received 1 November 2011; Accepted 29 December 2011

Academic Editor: Halis Oguz

Copyright © 2012 Somya A. Nassar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. F. Gracy, Infection of Rabbits and Horses. Meat Hygiene, Bailliere Tindall, Eastbourne, East Sussex, UK, 8th edition, 1986.
  2. D. H. Percy, J. F. Prescott, and J. L. Bhasin, “Inactivated bacterial antigen were complemented with adjuvents in order to increase the immunogenicity of the vaccines,” Journal of Complementary Medicine, vol. 46, pp. 227–229, 1985. View at Google Scholar
  3. L. Okerman and L. Spanoghe, “Protective effects of inactivated pasteurella vaccines in specific pathogen free rabbits,” Comparative Immunology, Microbiology and Infectious Diseases, vol. 4, no. 2, pp. 223–228, 1981. View at Publisher · View at Google Scholar
  4. T. Shawky, The immuno-potentiating Impact of zinc and vit. E in buffalo calves, M.S. thesis, Cairo University, Giza, Egypt, 1996.
  5. F. Amal, Pharmacological studies on Nigella sativa L on chickens infected with Salmonella typhimurium, M.S. thesis, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, 1997.
  6. A. M. Abd El-Fattah, E. M. Mohamed, E. Mohamed, and G. Ramadan, “Effect of thymus extract on immunologic reactivity of chicken vaccinated with infectious bursal disease virus,” Journal of Veterinary Medical Science, vol. 61, no. 7, pp. 811–817, 1999. View at Google Scholar · View at Scopus
  7. H. Koo, B. P. Gomes, P. L. Rosalen, G. M. Ambrosano, Y. K. Park, and J. A. Cury, “In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens,” Archives of Oral Biology, vol. 45, no. 2, pp. 141–148, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Nakamura, R. Nakamura, K. Watanabe et al., “Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis,” International Immunopharmacology, vol. 10, no. 9, pp. 1107–1112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. H. S. Vatansever, K. Sorkun, S. I. D. Gurhan et al., “Propolis from Turkey induces apoptosis through activating caspases in human breast carcinoma cell lines,” Acta Histochemica, vol. 112, no. 6, pp. 546–556, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Cetin, M. Kanbur, S. Silici, and G. Eraslan, “Propetamphos-induced changes in haematological and biochemical parameters of female rats: protective role of propolis,” Food and Chemical Toxicology, vol. 48, no. 7, pp. 1806–1810, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. S. Song, E. H. Park, G. M. Hur et al., “Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity,” Cancer Letters, vol. 175, no. 1, pp. 53–61, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. A. G. Hegazi, F. K. Abd El Hady, F. A. El Menway, and H. Al Mehdar, “Egyptian propolis: 5 influence of propolis adminestration on some chicken biochemical parameters,” Journal of Veterinary Science & Technology, vol. 1, pp. 43–58, 2004. View at Google Scholar
  13. H. Türkez, M. I. Yousef, and F. Geyikoglu, “Propolis prevents aluminium-induced genetic and hepatic damages in rat liver,” Food and Chemical Toxicology, vol. 48, no. 10, pp. 2741–2746, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Cruickshank, J. P. Duguid, B. P. Marmion, and R. H. A. Swain, Medical Microbiology, vol. 2, Churchill Livingstone, London, UK, 12th edition, 1975.
  15. B. F. Feldman, J. G. Zinkl, and N. C. Jain, Schalm's Veterinary Hemtology, Lea and Febiger, Philadelphia, Pa, USA, 5th edition, 2000.
  16. R. J. Henary, D. C. Cannon, and J. W. Winkleman, Clinical Chemistry Principles and Techniques, Harper and Roe, New York, NY, USA, 2nd edition, 1974.
  17. B. T. Doumas, W. A. Watson, and H. G. Biggs, “Albumin standards and the measurement of serum albumin with bromcresol green,” Clinica Chimica Acta, vol. 31, no. 1, pp. 87–96, 1971. View at Google Scholar · View at Scopus
  18. C. C. Allain, L. S. Poon, C. S. G. Chan, W. Richmond, and P. C. Fu, “Enzymatic determination of total serum cholesterol,” Clinical Chemistry, vol. 20, no. 4, pp. 470–475, 1974. View at Google Scholar · View at Scopus
  19. P. Fossati and L. Prencipe, “Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide,” Clinical Chemistry, vol. 28, no. 10, pp. 2077–2080, 1982. View at Google Scholar · View at Scopus
  20. P. Trinder, “Enzymatic methods for glucose determination,” Annals of Clinical Biochemistry, vol. 6, pp. 24–28, 1969. View at Google Scholar
  21. S. M. D. Reitman and S. Frankel, “A colorimeter method for determination of serum glutamic oxaloacetic acid and glutamic pyruvic acid transferases,” American Journal of Clinical Pathology, vol. 28, pp. 56–63, 1957. View at Google Scholar
  22. N. W. Tietz, Clinical Guide to Laboratory Tests, WB Saunders, Philadelphia, Pa, USA, 3rd edition, 1995.
  23. Q. Shu, H. Lin, K. K. J. Rutherfurd et al., “Dietary Bifidobacterium lactis (HN019) enhances resistance to oral Salmonella typhimurium infection in mice,” Microbiology and Immunology, vol. 44, no. 4, pp. 213–222, 2000. View at Google Scholar · View at Scopus
  24. R. G. D. Steel and J. H. Torrie, Principles and Procedures of Statistics, McGraw-Hill, New York, NY, USA, 1980.
  25. L. Pari and M. Gnanasoundari, “Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver,” Basic and Clinical Pharmacology and Toxicology, vol. 98, no. 5, pp. 456–461, 2006. View at Publisher · View at Google Scholar
  26. M. Kanbur, G. Eraslan, and S. Silici, “Antioxidant effect of propolis against exposure to propetamphos in rats,” Ecotoxicology and Environmental Safety, vol. 72, no. 3, pp. 909–915, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. A. A. Newairy, A. F. Salama, M. Hend, H. M. Hussien, and M. I. Yousef, “Propolis alleviates aluminium-induced lipid peroxidation and biochemical parameters in male rats,” Food and Chemical Toxicology, vol. 47, no. 6, pp. 1093–1098, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. C. L. Orsatti, F. Missima, A. C. Pagliarone, and J. M. Sforcin, “Th1/Th2 cytokines' expression and production by propolis-treated mice,” Journal of Ethnopharmacology, vol. 129, no. 3, pp. 314–318, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. V. Dimov, N. Ivanovska, V. Bankova, S. Popov, N. Manonlova, and N. Nikolov, “Immuno-modulatory action of propolis. Influnce on anti-infections protection and macrophage function,” Apidologie, vol. 22, no. 2, pp. 155–162, 1991. View at Publisher · View at Google Scholar
  30. J. Moriyasu, S. Arai, R. Motoda, and M. Kurimoto, “In vitro activation of mouse macrophage by propolis extract powder,” Biotherapy, vol. 8, pp. 364–368, 1994. View at Google Scholar
  31. S. Ansorge, D. Reinhold, and U. Lendeckel, “Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-β1 production of human immune cells,” Zeitschrift fur Naturforschung C, vol. 58, no. 7-8, pp. 580–589, 2003. View at Google Scholar · View at Scopus
  32. T. Kimoto, S. Arai, M. Kohguchi et al., “Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis,” Cancer Detection and Prevention, vol. 22, no. 6, pp. 506–515, 1998. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Orsolic and I. Basic, “Immuno-modulation by water-soluble derivatives of propolis: a factor of anti-tumour reactivity,” Journal of Ethnopharmacology, vol. 84, no. 2-3, pp. 265–273, 2003. View at Publisher · View at Google Scholar
  34. W. H. Chu, “Adjuvant effect of propolis on immunization by inactivated Aeromonas hydrophila in carp (Carassrus auratus gibelio),” Fish & Shellfish Immunology, vol. 21, pp. 113–117, 2006. View at Google Scholar
  35. Y. Onlen, C. Tamer, H. Oksuz, N. Duran, M. E. Altug, and S. Yakan, “Comparative trial of different anti-bacterial combinations with propolis and ciprofloxacin on Pseudomonas keratitis in rabbits,” Microbiological Research, vol. 162, no. 1, pp. 62–68, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. O. B. Borkowska, A. Kedrak, and M. Truszczynki, “Pasteurella multocida serum level in rabbits vaccinated against pasteruellosis,” Bulletin of the Veterinary Institute in Pulawy, vol. 40, pp. 97–104, 1996. View at Google Scholar
  37. O. B. Borkowska, A. Kedrak, and M. Truszczynki, “Application of the ELISA for determination of anti P. multocida IgG in sera of rabbit vaccinated against pasteurellosis under field condition,” Bulletin of the Veterinary Institute in Pulawy, vol. 41, pp. 17–24, 1997. View at Google Scholar
  38. Z. S. Talas and M. F. Gulhan, “Effects of various propolis concentrations on biochemical and hematological parameters of rainbow trout (Oncorhynchus mykiss),” Ecotoxicology and Environmental Safety, vol. 72, no. 7, pp. 1994–1998, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Eraslan, M. Kanbur, and S. Silici, “Evaluation of propolis effects on some biochemical parameters in rats treated with sodium fluoride,” Pesticide Biochemistry and Physiology, vol. 88, no. 3, pp. 273–283, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. A. M. Badawi, Some biochemical effects of the propolis under the normal conditions in rats, M.S. thesis, Faculty of Agriculture, Cairo University, Giza, Egypt, 1990.
  41. T. Ali, Effect of propolis as an antimicrobial substance on some biochemical change in infected rats, M.S. thesis, Faculty of science, Cairo University, Giza, Egypt, 1995.
  42. H. U. Fuliang, H. R. Hepburn, H. Xuan, M. Chen, S. Daya, and S. E. Radloff, “Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus,” Pharmacological Research, vol. 51, no. 2, pp. 147–152, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. M. J. Q. F. Alves, F. F. Mesquita, M. Sakaguti, and A. C. Tardivo, “Hypocholesterolemic effect of propolis' caffeic acids,” Revista Brasileira de Plantas Medicinais, vol. 10, no. 1, pp. 100–105, 2008. View at Google Scholar · View at Scopus
  44. Z. Kleinrok, Z. Borzecki, S. Scheller, and W. Matuga, “Biological properties and clinical application of propolis. X. Preliminary pharmacological evaluation of ethanol extract of propolis (EEP),” Arzneimittel-Forschung, vol. 28, no. 2, pp. 291–292, 1978. View at Google Scholar
  45. T. T. Oliveira, T. J. Nagem, and J. N. Ribeiro, “Serum activities of aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transpeptidase enzymes in rabbits treated with crude extract of propolis,” Revista de Ciencias Farmaceuticas Basica e Aplicada, vol. 26, no. 1, pp. 25–28, 2005. View at Google Scholar · View at Scopus
  46. J. M. Sforcin, R. O. Orsi, and V. Bankova, “Effect of propolis, some isolated compounds and its source plant on antibody production,” Journal of Ethnopharmacology, vol. 98, no. 3, pp. 301–305, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. R. O. Orsi, J. M. Sforcin, S. R. C. Funari, and V. Bankova, “Effects of Brazilian and Bulgarian propolis on bactericidal activity of macrophages against Salmonella typhimurium,” International Immunopharmacology, vol. 5, no. 2, pp. 359–368, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. J. H. Park, J. K. Lee, H. S. Kim et al., “Immuno-modulatory effect of caffeic acid phenyl ester in BALB/c,” International Immunopharmacology, vol. 4, no. 3, pp. 429–436, 2004. View at Publisher · View at Google Scholar
  49. A. Cuesta, A. Rodri, M. A. Esteban, and J. Meseguer, “In vivo effects of propolis, a honey bee product, on gilthead seabream innate immune responses,” Fish & Shellfish Immunology, vol. 18, no. 1, pp. 71–80, 2005. View at Publisher · View at Google Scholar
  50. S. K. Cho, J. M. Park, J. Y. Kim, and Y. D. Yoon, “Studies on the development of combined vaccine for control of snuffles (Pasteurella multocida, Bordetella bronchiseptica infection) in rabbits,” The Research Reports of the Rural Development Administration, vol. 31, no. 3, pp. 29–37, 1989. View at Google Scholar
  51. L. Z. Jarvinen, H. Hogenesch, M. A. Suckow, and T. L. Bowersock, “Induction of protective immunity in rabbits by coadministration of inactivated Pasteurella multocida toxin and potassium thiocyanate extract,” Infection and Immunity, vol. 66, no. 8, pp. 3788–3795, 1998. View at Google Scholar · View at Scopus
  52. N. Márquez, R. Sancho, A. Macho, M. A. Calzado, B. L. Fiebich, and E. Muñoz, “Caffeic acid phenethyl ester inhibits T-Cell activation by targeting both nuclear factor of activated T-Cells and NF-κB transcription factors,” Journal of Pharmacology and Experimental Therapeutics, vol. 308, no. 3, pp. 993–1001, 2004. View at Publisher · View at Google Scholar · View at Scopus
  53. F. Hu, H. R. Hepburn, Y. Li, M. Chen, S. E. Radloff, and S. Daya, “Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models,” Journal of Ethnopharmacology, vol. 100, no. 3, pp. 276–283, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. N. Paulino, C. Teixeira, R. Martins et al., “Evaluation of the analgesic and anti-inflammatory effects of a Brazilian green propolis,” Planta Medica, vol. 72, no. 10, pp. 899–906, 2006. View at Publisher · View at Google Scholar · View at Scopus