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The Scientific World Journal
Volume 2012, Article ID 908702, 6 pages
http://dx.doi.org/10.1100/2012/908702
Research Article

Eutectic Salt Catalyzed Environmentally Benign and Highly Efficient Biginelli Reaction

1Chemistry & Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran 1496813151, Iran
2Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

Received 8 October 2011; Accepted 21 November 2011

Academic Editors: V. Capriati and R. A. Fernandes

Copyright © 2012 Najmadin Azizi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple deep eutectic solvent based on tin (II) chloride was used as a dual catalyst and environmentally benign reaction medium for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives, from aromatic and aliphatic aldehydes, 1,3-dicarbonyl compounds, and urea in good-to-excellent yields and short reaction time. This simple ammonium deep eutectic solvent, easily synthesized from choline chloride and tin chloride, is relatively inexpensive and recyclable, making it applicable for industrial applications.