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The Scientific World Journal
Volume 2012, Article ID 916587, 6 pages
http://dx.doi.org/10.1100/2012/916587
Clinical Study

The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population

1Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2Cancer Center, Kaohsiung Medical University Hospital, 100 TzYou First Road, Kaohsiung City 807, Taiwan
3School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City 110, Taiwan
4Department of Molecular Biology and Human Genetics, Tzu Chi University, Zhongyang Rd., Sec. 3, Hualien 97004, Taiwan
5Department of Tumor Biology, Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center, Tampa, FL 12902, USA
6Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, 100 TzYou First Road, Kaohsiung 807, Taiwan
7National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung 807, Taiwan
8Division of General & Gastroenterological Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan

Received 25 February 2012; Accepted 10 April 2012

Academic Editors: G. Frosina and Z. Wang

Copyright © 2012 Wei-Chiao Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) >10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (χ2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.