Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives

Table 1

Acute anti-inflammatory activity of 1,2,3-triazole phthalimides 3a–c and 5a–c after carrageenin-induced edema at dose 250 mg·kg⁻¹.

Compounds	Difference in paw weight (g) ± SEM	Edema inhibition (%)
3a	0.1030 ± 0.0129**	33.7
3b	0.0485 ± 0.0160**	69.0
3c	0.0865 ± 0.0385**	44.0
5a	0.1247 ± 0.0119**	17.0
5b	0.1166 ± 0.0308*	25.0
5c	0.0680 ± 0.0128**	56.2
1% Carboxymethylcellulose	0.1461 ± 0.0168^ns	6.0
0.9% saline solution	0.1553 ± 0.0172^ns	—
Ibuprofen	0.0421 ± 0.0134**	73.0
ASA	0.0502 ± 0.0237**	68.0

Significant differences: *P < 0.05; **P < 0.001; ns: not significant.