Large Scale Association Analysis for Drug Addiction: Results from SNP to Gene

Table 2

Summary of the candidate genes identified by the gene-based and SNP-based methods.

Chr	Gene	Source	P value (gene-based)^a	Min P value (SNP-based)^b	Detected SD^c	Reported SD	Reference
1	KIAA0040	White women	3.75𝐸−05	2.60𝐸−06	Alcohol	Alcohol	[27, 44]
2	HAAO	White women	4.40𝐸−04	3.02𝐸−05	Cocaine	Alcohol	[41]
2	NCK2	Black men	2.70𝐸−06	1.10𝐸−07	Opiates	NA	NA
3	SH3BP5	White men	1.20𝐸−04	4.24𝐸−06	Cocaine	Alcohol	[13]
4	MANBA	White men	4.63𝐸−04	3.47𝐸−05	Alcohol	Alcohol	[29]
7	RELN	White men	8.53𝐸−04	5.32𝐸−06	Cocaine	Smoking	[37]
8	CSMD1	Black women	1.23𝐸−02	8.50𝐸−06	Nicotine	Smoking	[37, 38]
11	LRP5	White men	4.01𝐸−05	1.58𝐸−06	Opiates	Smoking	[42]
11	PKNOX2	White women	1.84𝐸−04	2.20𝐸−06	Alcohol	Alcohol	[13, 27, 41]
12	IFNG	White women	1.16𝐸−04	1.57𝐸−05	Opiates	Smoking	[37]
18	FAM38B	Black women	9.24𝐸−04	5.61𝐸−06	Cocaine	Smoking	[40]
18	PTPRM	Black women	2.21𝐸−3	9.50𝐸−06	Marijuana	Alcohol	[43]
22	MAPK1	Black women	2.79𝐸−04	3.52𝐸−05	Marijuana	Alcohol	[25]

^aP value (gene-based): the P value obtained by the gene-based association test;
^bmin P value (SNP-based): the minimal P value of the SNPs within the corresponding gene;
^cSD: substance dependence.