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The Scientific World Journal
Volume 2012, Article ID 946954, 6 pages
http://dx.doi.org/10.1100/2012/946954
Research Article

Risk Factors for Infection with Different Hepatitis C Virus Genotypes in Southern Brazil

1Universidade Regional Integrada Campus Erechim, Erechim, Brazil
2National Institute of Science and Technology for Health Technology Assessment (IATS)-CNPq, Porto Alegre, Rio Grande do Sul, Brazil
3Post-Graduate Program in Medicine (Epidemiology)-Federal University of Rio Grande do Sul, Porto Alegre, Brazil
4Pharmacology Department, Ciências Básicas da Saúde Institute, Federal University of Rio Grande do Sul, Brazil

Received 23 January 2012; Accepted 19 February 2012

Academic Editors: G. A. Abrams, A. Arminio Monforte, H. Fickenscher, and S. Litvak

Copyright © 2012 Marisa Lúcia Romani Paraboni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To investigate the proportion of different genotypes in countryside microregions in southern Brazil, and their association with risk factors. Methods. Cross-sectional study including a convenience sample of patients who tested positive for HCV-RNA and were referred to a regional health center for genotyping, from December 2003 to January 2008. Data were obtained through the National Disease Surveillance Data System, from laboratory registers and from patient charts. Identification of genotypes was carried out using the Restriction Fragment Length Polymorphism “in house” technique. Independent associations with genotypes were evaluated in multinomial logistic regression and prevalence rates of genotypes were estimated with modified Poisson regression. Results. The sample consisted of 441 individuals, 4 1 . 1 ± 1 2 . 0 years old, 56.5% men. Genotype 1 was observed in 41.5% (95% CI 37.9–48.1) of patients, genotype 2 in 19.3% (95% CI 15.0–23.6), and genotype 3 in 39.2% (95% CI 35.6–43.0). HCV genotype was significantly associated with gender and age. Dental procedures were associated with higher proportion of genotype 2 independently of age, education, and patient treatment center. Conclusions. The hepatitis C virus genotype 1 was the most frequent. Genotype 2 was associated with female gender, age, and dental procedure exposition.