Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease
Table 2
Effect of CDAA diet on serum ALT, serum AST, and liver triglyceride levels in the and mice.
CDAA diet consumption
0 wk
2 wk
4 wk
8 wk
Serum ALT (IU/L)
26.9 ± 4.3
48.2 ± 9.8
89.9 ± 33.3
64.2 ± 17.5
19.7 ± 1.0
109.6 ± 18.3*
151.2 ± 45.6
260.9 ± 101.6
Serum AST (IU/L)
78.6 ± 7.6
80.7 ± 10.7
117.6 ± 27.3
75.7 ± 9.5
78.5 ± 11.5
114.9 ± 15.1
153.7 ± 26.6
192.1 ± 39.9*
Liver triglyceride (mg/g)
13.3 ± 0.5
51.7 ± 3.4
64.9 ± 5.6
75.1 ± 1.7
15.7 ± 1.0
58.1 ± 4.1
66.0 ± 4.0
88.1 ± 10.7
Results are expressed as mean ± SEM of the values from 4–6 mice in each group. * in comparison with gal3+/+ mice. CDAA: choline-deficient L-amino-acid-defined diet; ALT: alanine aminotransferase; AST: aspartate aminotransferase.
