The Scientific World Journal

Research Article

Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease

Table 3

Effect of CDAA diet and galectin-3 deficiency on the severity of hepatic steatosis and necroinflammation.
CDAA diet consumption
0 wk2 wk4 wk8 wk
Steatosis G a l 3 + / + 0.0 ± 0.00.6 ± 0.51.5 ± 0.62.3 ± 1.0
G a l 3 − / − 0.0 ± 0.02.0 ± 0.7*2.8 ± 0.5*2.8 ± 0.5
Necroinflammation G a l 3 + / + 0.0 ± 0.00.6 ± 0.51.5 ± 0.62.0 ± 0.0
G a l 3 − / − 0.0 ± 0.01.8 ± 0.4*1.8 ± 0.52.0 ± 0.0
The severity of both hepatic steatosis and necroinflammation was scored on a scale of 0–3, as described in Materials and Methods. Results are expressed as mean ± SEM of the values from 4–6 mice in each group. * 𝑃 < 0 . 0 5 in comparison with g a l 3 + / + mice.