The Scientific World Journal

Research Article

Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease

Table 4

Genetic networks with high scores (>15) in g a l 3 āˆ’ / āˆ’ mice with CDAA diet-induced NAFLD.
NetworkGenetic in Ingenuity networksaScoreFocus genesTop functions
1ACTG1, ANXA2, AP3D1, CA3, CD36, CD151, CEACAM1, COTL1, CTSB, DNMT3A, ETS2, FOS, GAS1, GSTA5, GSTM3, HNRPAB, IFRD1, ITGA2B, JUN, MT1A, MT2A, MTF1, NMI, PBX2, RBM39, RBP1, RPL39, S100A10, SERPINA3G, SLPI, SPP1, TGM2, TMED10, TTRAP, TUBB2A4935Cancer, cell death, cellular assembly and organization
2BAG3, BMPR1A, C5ORF13, CD2AP, COL1A1, COL3A1, DIO1, DNAJB1, HDAC3, HSP90AA1, HSPA8, HSPA1A, HSPH1, IFIH1, IRF3, KLF6, KPNA4, LIFR, MBD1, P4HA1, PDGFC, PDGFRB, PPP1CB, PTPN2, RHOB, RND3, ROCK1, SERPINH1, STAT1, TANK, TBK1, TFRC, TGFBR2, TGTP, USP184935Cellular function and maintenance, dermatological diseases and conditions, organismal injury and abnormalities
3ABCB11, ABCC3, BRD8, CDC20, CDH1, CPT1A, CSNK2A2, CYP3A5, CYP4A22, CYP7A1, DLG1, DNAJB4, DUSP6, FOXA1, G6PC, GADD45A, GADD45G, GCK, HNRPH2, IGHM, INSIG2, IQGAP1, LCN2, LGALS1, MAP3K4, PCK1, PPARGC1B, PTPRC, RXRA, SCD, SMAD4, SQLE, SSRP1, SUB1, TMSB4X4935Carbohydrate metabolism, cell death, cancer
4ACSL4, AFP, ALDOC, ARF6, ARMET, CES1, COL5A2, DUSP6, EGLN3, ENPP1, ERBB2, GJA1, HAS2, HGF, HIF1A, HRAS, LCN2, LDHA, LGALS1, NDST1, NID1, PDLIM1, PGAM1, PGF, PLOD1, PQLC1, PRDX2, RHOB, S100A4, SPRY2, SQLE, TMSB4X, TSC22D1, TSC22D4, UCRC2021Cancer, cellular movement, reproductive system disease
5ABCB1, ATF3, ATR, CASP4, CCNG1, CEBPD, CHUK, CSF1R, DUSP1, FOXO3A, GBP4, GPIAP1, GSTM5, H2AFZ, HSP90AA1, IFIT1L, ISG15, MCM2, MCM3, MCM4, MCM6, MDM2, NOX4, PDCD6IP, POLB, PPP2R4, RALGPS2, SON, SPP1, STRN3, SUMO1, TANK, TP53, UBQLN1, WT11920Cancer, cell cycle, reproductive system disease
6ANXA2, CD14, CIITA, COL4A2, COL6A1, COL6A2, COL6A3, CREB1, ELN, EMILIN1, FGF10, GNAS, IRF7, LDHA, MAPKAPK2, MFI2, NCL, OAT, OPRM1, PCSK1, PITPNB, PLEKHC1, PTHLH, S100A11, SCD, SCOTIN, SEC63, SFTPB, SSTR2, TGFB1, TGM1, TH, TMEM123, TNFRSF10A, VNN11719Genetic disorder, skeletal and muscular disorders, dermatological diseases and conditions
7ACVR1, AKAP12, CD14, CD53, CEACAM5, CEBPA, CPB2, CSF1R, CYP3A5, DDIT3, EPAS1, FCGR1A, GAL, HP, IGSF1, IK, IL6, INHBA, INHBC, INHBE, ITGA2B, LGALS4, LOX, PGD, PSCDBP, PTPRC, PTPRZ1, SAA1, SLCO1A1, SOAT1, SPBC25, STAR, TRIB1, UCP1, USP521719Lipid metabolism, molecular transport, small molecule biochemistry
8ALDOB, APOM, ARPC4, ATP6V1E1, CD14, CD36, CEBPB, CPS1, CSF3, CSTB, CXCL6, CYP24A1, CYP4A22, CYP7A1, ELOVL3, FABP3, FGF19, HCA112, LCN2, LEP, MBOAT5, NFKBIZ, NRG1, ORM1, PDK4, PPARA, PTGER4, SCD, SLC10A2, SLC20A1, SRXN1, TNFSF11, TRAF6, UGP2, ZNF2741719Carbohydrate metabolism, molecular transport, small molecule biochemistry
aGenes colored red or green are those identified by microarray analysis as upregulated and downregulated, respectively.