The Scientific World Journal / 2012 / Article / Fig 6

Clinical Study

B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency

Figure 6

CXCL16high B cell responses to CpG. (a) Evaluation of target gene (mRNA levels) upregulation (mRNA levels) after in vitro stimulation with CpG. Fold increase of CD69, CD86, TLR9, AICDA, and IL-6 at the mRNA level after CpG stimulation. Experiments were performed with PBMCs in triplicates for all patients ( š¯‘› = 1 5 ) and healthy controls ( š¯‘› = 8 ). (b) Fold increase of TLR9, AICDA, and IL-6 at the mRNA level after CpG stimulation. Experiments were performed with purified B cells from patients ( š¯‘› = 5 ) and healthy controls ( š¯‘› = 2 ). Graph bars show standard error (SE). (c) Evaluation of target gene (mRNA levels) upregulation (mRNA levels) after TNF-Ī± blockade and in vitro stimulation with CpG. Fold variation of CD69, CD86, TLR9, AICDA, and IL-6 at the mRNA level is showed. Experiments were performed with PBMCs in triplicates for all patients ( š¯‘› = 1 5 ) and healthy controls ( š¯‘› = 8 ). Graph bars show standard error (SE).
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(a)
960219.fig.006b
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