Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats

Figure 1

PAI–1 blood level (ng/mL) in Wistar rats fed normocholesterolaemic diet. K_N: normocholesterolaemic control group, IW_N: normocholesterolaemic group receiving ivabradine, S1_N: normocholesterolaemic group receiving simvastatin at a dose of 1 mg × kg⁻¹ bw, S20_N: normocholesterolaemic group receiving simvastatin at a dose of 20 mg × kg⁻¹ bw, IW_N_S1: normocholesterolaemic group receiving ivabradine and simvastatin at a dose of 1 mg × kg⁻¹ bw, IW_N_S20: normocholesterolaemic group receiving ivabradine and simvastatin at a dose of 20 mg × kg⁻¹ bw, ^∗𝑃<0.05 as compared to the control group, (a) 𝑃<0.05 as compared to rats receiving simvastatin alone, and (b) 𝑃<0.05 as compared to rats receiving ivabradine alone.