Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats

Table 3

Summary statistics (mean ± SD) for blood pressure (mmHg) in normocholesterolaemic rats.

	Systolic blood pressure (mmHg)	Mean blood pressure (mmHg)	Diastolic blood pressure (mmHg)
K_N	105,57 ± 2,58	93,40 ± 4,55	83,96 ± 2,23
IW_N	106,66 ± 2,93	93,47 ± 3,27	85,97 ± 2,25
S1_N	104,53 ± 3,05	93,50 ± 3,13	84,63 ± 2,85
S20_N	106,79 ± 3,44	93,56 ± 5,33	86,92 ± 3,17
IW_N_S1	105,97 ± 4,37	93,51 ±4,10	85,48 ± 3,35
IW_N_S20	106,07 ± 5,12	92,95 ± 3,52	84,53 ± 2,82

K_N: normocholesterolaemic control group, IW_N: normocholesterolaemic group receiving ivabradine, S1_N: normocholesterolaemic group receiving simvastatin at a dose of 1 mg × kg⁻¹ bw, S20_N: normocholesterolaemic group receiving simvastatin at a dose of 20 mg × kg⁻¹ bw, IW_N_S1: normocholesterolaemic group receiving ivabradine and simvastatin at a dose of 1 mg × kg⁻¹ bw, IW_N_S20: normocholesterolaemic group receiving ivabradine and simvastatin at a dose of 20 mg × kg⁻¹ bw.