Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

Table 2

Comparison of the effect of ML on microscopic damage caused by Mtx in liver.

Parameters	Control	ML	Mtx	Mtx + ML	ML + Mtx
Microscopic; damage	0.3 ± 0.5	0.8 ± 0.9	4.7 ± 0.9^a	3.3 ± 0.5^b,c	3.2 ± 0.7^b

^aSignificantly increased when compared with control group, 𝑃=0.001.
^bSignificantly decreased when compared with Mtx group, 𝑃=0.005 and 𝑃=0.01.
^cNo significance when compared with ML + Mtx, 𝑃=0.8.