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The Scientific World Journal
Volume 2013, Article ID 131358, 9 pages
http://dx.doi.org/10.1155/2013/131358
Research Article

Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins Using Two-Compartment Mathematical Model

Department of Anaesthesia and Critical Care, University of Würzburg, 97080 Würzburg, Germany

Received 3 August 2013; Accepted 6 September 2013

Academic Editors: A. Nokhodchi and M. Ozyazici

Copyright © 2013 Sergey Shityakov and Carola Förster. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl- -cyclodextrin (NC/HP CD) and hydrophobic triacetyl- -cyclodextrin (NC/TA CD), through the body for controlled drug delivery and sustained release have been examined. The two-compartment pharmacokinetic model described the mechanisms of how the human body handles with ingestion of NC-cyclodextrin complexes in gastrointestinal tract (GI), distribution in plasma, and their metabolism in the liver. The model showed that drug bioavailability was significantly improved after oral administration of cyclodextrin complexes. The mathematical significance of this study to predict nicardipine delivery using pharmacokinetic two-compartment mathematical model with linear ordinary differential equations (ODE) approach represents a valuable tool to emphasize its effectiveness and metabolizing rate and diminish the side effects.