Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins Using Two-Compartment Mathematical Model

Table 2

Refined rate constants calculated from the predicted (GI) and experimental (Plasma) 𝑡_1/2 data [1].

Compound	𝑘GI^∗ (mL/min)	𝑘Plasma^∗ (mL/min)
NC	3.18	0.99
NC/HPβCD	0.59	0.43
NC/TAβCD	1.0	0.29

𝑘_GI^∗=𝑘_GI/Fold;𝑘_Plasma^∗=𝑘_Plasma/Fold;Fold=𝑇_max𝐶^pre_max/𝑇^pre_max𝐶_max.