Structure-Activity Relationships of 3,3′-Phenylmethylene-bis-4-hydroxycoumarins: Selective and Potent Inhibitors of Gram-Positive Bacteria

<table>Comparative model of <i>S. aureus</i> azoreductase in complex with FMN and dicoumarol. The protein model is a homodimer composed of two ligand-binding sites located at the dimer interface. FMN, dicoumarol (DTC), and the conserved binding residues are shown in stick representation.</table>

The Scientific World Journal

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Figure 3

Figure 3: Structure-Activity Relationships of 3,3′-Phenylmethylene-bis-4-hydroxycoumarins: Selective and Potent Inhibitors of Gram-Positive Bacteria 