Maternal and Foetal Cardiovascular Effects of the Anaesthetic Alfaxalone in 2-Hydroxypropyl-β-cyclodextrin in the Pregnant Ewe

Table 1

Changes in maternal cardiovascular variables following administration of a single intravenous bolus of 2 mg/kg of alfaxalone in a 2-hydroxypropyl-β-cyclodextrin formulation (mean ± SD).

	HR (bpm)	SAP (mm Hg)	DAP (mm Hg)	MAP (mm Hg)	RR (rpm)
Baseline values	126.00±20.56	96.00±19.06	63.16±14.71	760.50±16.18	48.83±15.98
2 min	130.60±16.86	81.16±16.00	57.16±40.60	67.00±39.02	30.00±8.29
5 min	133.40±18.80	90.00±19.66	65.5±19.59	73.16±16.43	29.33±13.54
10 min	134.20±23.49	103.3±25.15	80.83±14.16	88.67±19.02	37.00±14.41
15 min	134.50±28.72	102.7±14.45	79.00±14.41	86.83±13.01	39.67±14.56
20 min	140.20±24.63	101.50±10.23	78.67±11.47	87.5±10.03	39.67±8.98
30 min	150.30±24.48	93.5±17.63	64.00±10.90	73.83±9.84	42.67±11.22
45 min	133.20±12.92	96.33±18.18	64.17±20.72	78.00±19.24	47.33±9.26
60 min	130.80±18.73	91.8±13.54	64.00±7.24	74.00±10.61	57.00±25.73
90 min	115.00±13.37	89.8±19.76	53.80±15.15^∗	63.00±13.32	62.40±26.32
120 min	117.75±25.95	81.6±8.23	50.60±17.99^∗	63.8±14.41	71.20±36.15
150 min	125.20±12.02	93.25±17.85	56.00±25.17^∗	71.75±20.18	60.80±41.12
180 min	120.80±12.81	80.2±10.47	59.8±15.31^∗	68.4±12.58	57.60±36.50
210 min	121.60±15.37	91.6±12.22	61.20±22.55^∗	74.80±17.22	48.00±14.42
240 min	109.50±12.71	90.80±24.78	62.00±32.83^∗	76.00±27.91	50.80±20.95

∗Significant differences from min 10.
HR: heart rate; SAP: systolic arterial pressure; DAP: diastolic arterial pressure; MAP: mean arterial pressure; RR: respiratory rate.