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The Scientific World Journal
Volume 2013, Article ID 194918, 4 pages
Clinical Study

Children with Congenital Hypothyroidism Have Similar Neuroradiological Abnormal Findings as Healthy Ones

1Pediatric Endocrinology Service, Division of Pediatric, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Zerifin 70300, Israel
2Division of Endocrinology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
3Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
4Department of Psychology and Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8
5Neuroscience and Mental Health Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8

Received 9 August 2013; Accepted 2 September 2013

Academic Editors: D. Caselli and F. Kneepkens

Copyright © 2013 Marianna Rachmiel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To assess the neuroradiological findings of children with congenital hypothyroidism (CHT) compared to healthy controls (HC). Patients and Methods. Thirty children with CHT, mean age 12.5 ± 1.6 years, 14 (44.8%) males, were compared with 38 HC mean age 11.7 ± 1.7 years, 16 (45.7%) males. Clinical data were collected from medical charts and questionnaires seeking information on family history, birth and perinatal period events, medications, and overall health history. Neurocognitive function was assessed for global intelligence, visual and verbal memory, and executive functioning using standardized tests. Neuroimaging was performed using 1.5 T magnetic resonance imaging and assessed by two pediatric radiologists. Results. Children with CHT had a similar proportion of incidental findings as did the children in the HC group, at 43.3% and 39.5%, respectively, . Abnormalities of the sellar region were reported in 13.3% of CHT group and 7.9% of HC group, . Other incidental findings included cerebellar ectopia, choroidal fissure and pineal cysts, and multiple increased signal intensity foci. Neuroradiological findings were not associated with clinical and neurocognitive abnormalities. Conclusion. Neuroimaging of children with CHT demonstrated a similar incidence of structural abnormalities as in the healthy population. There is no association between those findings and neurocognitive function.