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The Scientific World Journal
Volume 2013, Article ID 195028, 11 pages
http://dx.doi.org/10.1155/2013/195028
Review Article

Biophysical Insights into Cancer Transformation and Treatment

1Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, AS CR, Chaberská 57, 182 51 Prague 8-Kobylisy, Czech Republic
2Institute of Translational Pharmacology, National Research Council-CNR, Via Fosso del Cavaliere 100, 00133 Rome, Italy
3University of Applied Sciences of Southern Switzerland-SUPSI, Department of Innovative Technologies, Galleria 2, 6928 Manno, Switzerland
41st Faculty of Medicine, Charles University in Prague, Department of Obstetrics and Gynaecology, Apolinářská 18, 128 00 Prague 2, Czech Republic
5Faculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, 166 27 Prague 6, Czech Republic
6Faculty of Biomedical Engineering, Czech Technical University in Kladno, Sitná Square 3105, 272 01 Kladno, Czech Republic
71st Faculty of Medicine, Charles University in Prague, Institute of Physiology, Albertov 5, 128 00 Prague 2, Czech Republic
83rd Faculty of Medicine, Charles University in Prague, Department of Otorhinolaryngology, Ruská 87, 100 00 Prague 10, Czech Republic
9Department of Physics, University of Alberta, Edmonton, AB, Canada T6G 2J7

Received 31 January 2013; Accepted 9 May 2013

Academic Editors: A. Kukol, B. Schneider, and L. Strasak

Copyright © 2013 Jiří Pokorný et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields generated by microtubules. Microtubules and mitochondria colocalize in cells with microtubules providing tracks for mitochondrial movement. Besides energy transformation, mitochondria form a spatially distributed proton charge layer and a resultant strong static electric field, which causes water ordering in the surrounding cytosol. These effects create conditions for generation of coherent electrodynamic field. The metabolic energy transduction pathways are strongly affected in cancers. Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra. Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis. A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells. Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function.