Mortality Predicted Accuracy for Hepatocellular Carcinoma Patients with Hepatic Resection Using Artificial Neural Network

Table 1

Potential input variables and output variable for prognostic models.

Variables	Value	𝑃  value
Input variable:
Demographic
Age (years)*	0: ≦65, 1: >65 (mean = 57.7)	0.04
Gender	0: male, 1: female	0.37
Clinical features
Comorbidity*	0: no, 1: yes	0.04
Liver cirrhosis*	0: no, 1: yes	<0.001
Chronic hepatitis	0: no, 1: HBV, 2: HCV, 3: HBCV	0.68, 0.12, 0.48
α-Fetoprotein (ng/mL)*	0: ≦100, 1: >100	<0.001
AST (U/L)*	0: ≦80, 1: >80	<0.001
ALT (U/L)	0: ≦80, 1: >80	0.07
Total bilirubin (mg/dL)*	0: ≦1.0, 1: >1.0	0.01
Albumin (g/dL)*	0: >3.5, 1: ≦3.5	<0.001
BUN (mg/dL)*	0: ≦21, 1: >21	0.01
Creatinine (mg/dL)	0: ≦1.4, 1: >1.4	0.24
Platelet (10^3/μL)*	0: >150, 1: ≦150	0.02
Prothrombin time (%)	0: ≦80, 1: >80	0.43
ICGR15 (%)	0: ≦15, 1: >15	0.30
ASA classification*	0: ASA = 1, 1: ASA = 2, 2: ASA = 3	0.01, 0.94
Child-Pugh classification*	0: A, 1: B, C	<0.001
TNM Stage*	0: I, 1: II, 2: IIIa, IIIb, IIIc, IV	<0.001, <0.001
Tumor number*	0: single, 1: multiple	<0.001
Tumor size (cm)*	0: ≦5, 1: >5	<0.001
Portal vein invasion*	0: no, 1: yes	<0.001
Biliary invasion*	0: no, 1: yes	0.01
Surgical process and outcome
Surgical procedure*	0: laparoscopic, 1: open surgery	0.02
Extent of resection	0: minor, 1: major	0.12
Resection margin (mm)	0: >10, 1: ≦10	0.08
Surgical time (minutes)	0: ≦180, 1: >180	0.75
Blood loss (mL)	0: ≦1000, 1: >1000	0.29
Blood transfusion	0: no, 1: yes	0.55
Blood transfusion (mL)	0: ≦1000, 1: >1000	0.07
Postoperative complication*	0: no, 1: yes	<0.001
Prognostic
Recurrence*	0: no, 1: yes	<0.001
Preoperative treatment	0: no, 1: yes	0.08
Postoperative treatment*	0: no, 1: yes	<0.001
Output variable:
Status	0: survival, 1: dead

∗Significant input variables.