Tumor Necrosis Factor-Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease

Table 3

Haplotype analysis of TNF-α −1031T>C and −863C>A polymorphisms in the study population.

TNF-𝛼 −863C/A, TNF-𝛼 −1031T/C	Controls 𝑛 (% age) 310 (100)	Patients 𝑛 (% age) 310 (100)	𝜒^2	95% CI	P value
C-T	433 (70)	355 (57)	Reference
A-T	39 (6)	110 (18)	40.36	3.44(2.326–5.088)	<𝟎.𝟎𝟎𝟎𝟏^∗
C-C	69 (11)	44 (7)	1.259	0.77(0.519–1.164)	0.226
A-C	79 (13)	111 (18)	10.44	1.71(1.243–2.362)	𝟎.𝟎𝟎𝟏^∗

P value calculated by Chi-square stest (Yates corrected).
∗P value (<0.05) indicates statistical significance.
n: number; OR: odds ratio; CI: confidence interval.