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The Scientific World Journal
Volume 2013, Article ID 237438, 6 pages
http://dx.doi.org/10.1155/2013/237438
Research Article

Antimicrobial, Antiparasitic, Anti-Inflammatory, and Cytotoxic Activities of Lopezia racemosa

1Department of Medicine, Division of Infectious Diseases, University of British Columbia, 410-2660 Oak Street, Vancouver, BC, Canada V6H 3Z5
2Departamento de Ciencias Químico-Biológicas, Universidad de las Américas Puebla, Cholula, 72810 Puebla, PUE, Mexico
3Departamento de Ciencias Biológicas, Facultad Biotecnoambiental, Universidad Popular Autónoma del Estado de Puebla, 72410 Puebla, PUE, Mexico

Received 25 April 2013; Accepted 27 May 2013

Academic Editors: V. C. Filho and D. X. Tan

Copyright © 2013 Carla Cruz Paredes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to investigate the cytotoxicity of the compounds. Various extracts and fractions showed antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. The hexanic fraction HF 11-14b was the most interesting fraction with antimicrobial, and anti-inflammatory activities. The benefit of L. racemosa as a traditional medicinal plant was confirmed as shown by its antibacterial, antifungal and anti-inflammatory activities. To the best of our knowledge, this is the first study reporting the biological activities of L. racemosa, including antiparasitic and anti-inflammatory activities.