The Anticonvulsant Enaminone E139 Attenuates Paclitaxel-Induced Neuropathic Pain in Rodents
Figure 3
Effect of treatment with E139 on BALB/c mice with paclitaxel-induced thermal hyperalgesia in a hot-plate test. (a) Thermal hyperalgesia in BALB/c mice at day 7 after first inoculation of paclitaxel (administered at 2 mg/kg, i.p. for 5 consecutive days). Each point represents the mean ± S.E.M of values obtained from 22 vehicle-treated and 94 paclitaxel-treated animals. compared to drug vehicle at the same day after treatment and compared to pretreatment (PRE) values (Student’s -test). (b) Percentage change in reaction latency times from baseline values (taken at day 7 after first administration of paclitaxel) at different times after treatment with E139 (10–40 mg/kg) or its vehicle in hot-plate test. Each bar represents the mean ± S.E.M of values obtained from 12 animals. compared to drug vehicle at the same time point after treatment (two-way repeated measures ANOVA followed by Bonferroni test).
