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The Scientific World Journal
Volume 2013 (2013), Article ID 245828, 4 pages
http://dx.doi.org/10.1155/2013/245828
Research Article

Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass)

Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Avenida Normalistas 800, Colonia Colinas de la Normal, Guadalajara 44270, JAL, Mexico

Received 30 August 2013; Accepted 23 September 2013

Academic Editors: D. Matthopoulos and I. V. Sharakhov

Copyright © 2013 Eduardo Padilla-Camberos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract of Persea americana was evaluated with respect to its genotoxic potential through micronucleus assay in rodents. The frequency of micronuclei in groups of animals treated with avocado seed extract showed no differences compared to the negative control (vehicle); therefore, it is considered that the avocado seed extract showed no genotoxic activity in the micronucleus test.