Genotoxicity Assessment of Multispecies Probiotics Using Reverse Mutation, Mammalian Chromosomal Aberration, and Rodent Micronucleus Tests

Table 1

Chemical substances and concentrations used as positive controls for reverse mutation assay.

Strain	(−) S9 mix		(+) S9 mix
	Chemical substance	Conc.; (μg/plate)	Chemical substance	Conc.; (μg/plate)
TA97	4-Nitroquinoline-N-oxide	0.5	2-Aminofluorene	4.0
TA98	4-Nitroquinoline-N-oxide	0.5	Benzo[a]pyrene	4.0
TA100	Sodium azide	0.4	2-Aminofluorene	4.0
TA102	Mitomycin C	0.5	Benzo[a]pyrene	4.0
TA1535	Sodium azide	0.4	2-Aminoanthracene	4.0