Intranuclear Crosstalk between Extracellular Regulated Kinase1/2 and Signal Transducer and Activator of Transcription 3 Regulates JEG-3 Choriocarcinoma Cell Invasion and Proliferation

<table>Scheme of the proposed LIF signaling pathway in trophoblasts. Red lines demonstrate the major findings of this paper: LIF triggers activation of JAK/STAT and MAPK pathways independently. ERK1/2 does not induce STAT3 (ser727) phosphorylation but antagonizes STAT3 DNA-binding capacity in the nucleus. JAK/STAT and MAPK activation result in different cell-responses: increase of invasiveness and proliferation, respectively.</table>

The Scientific World Journal

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Figure 7

Figure 7: Intranuclear Crosstalk between Extracellular Regulated Kinase1/2 and Signal Transducer and Activator of Transcription 3 Regulates JEG-3 Choriocarcinoma Cell Invasion and Proliferation 

Figure 7 | Intranuclear Crosstalk between Extracellular Regulated Kinase1/2 and Signal Transducer and Activator of Transcription 3 Regulates JEG-3 Choriocarcinoma Cell Invasion and Proliferation 