The Scientific World Journal / 2013 / Article / Fig 3

Review Article

Renin and the IGFII/M6P Receptor System in Cardiac Biology

Figure 3

Structure of the IGFII/M6P receptor. The receptor has a cytoplasmic tail that triggers receptor internalization and signalling, a small transmembrane domain, and a large extracellular domain with 15 repeating segments. Mannose-6-phosphate labelled ligands (red symbol with white box for mannose-6-phosphate) bind to repeating segments 3 and 9. Unlike this schematic overview the most likely appearance of this receptor in living cells is that of a dimer.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.