Renin and the IGFII/M6P Receptor System in Cardiac Biology

Figure 3

Structure of the IGFII/M6P receptor. The receptor has a cytoplasmic tail that triggers receptor internalization and signalling, a small transmembrane domain, and a large extracellular domain with 15 repeating segments. Mannose-6-phosphate labelled ligands (red symbol with white box for mannose-6-phosphate) bind to repeating segments 3 and 9. Unlike this schematic overview the most likely appearance of this receptor in living cells is that of a dimer.